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Anti-aging Ingredient DPHP Dipalmitoyl Hydroxyproline CAS No.: 41672-81-5

Hydroxyproline is a primary amino acid in skin collagen. As a lipid-soluble derivative of hydroxyproline, Dipalmitoyl Hydroxyproline (DPHP) readily penetrates the dermis to stimulate collagen synthesis. Extensive scientific studies demonstrate DPHP’s efficacy in anti-aging and skin-firming.
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1. Product Details

INCI Name: Dipalmitoyl Hydroxyproline

INCI: Dipalmitoyl Hydroxyproline
CAS No.: 41672-81-5

Product Description
Hydroxyproline is a primary amino acid in skin collagen. As a lipid-soluble derivative of hydroxyproline, Dipalmitoyl Hydroxyproline (DPHP) readily penetrates the dermis to stimulate collagen synthesis. Extensive scientific studies demonstrate DPHP’s efficacy in anti-aging and skin-firming.

Key Functions
Stimulates collagen synthesis – Enhances skin elasticity while reducing wrinkle count and depth.

Inhibits elastase activity – Minimizes degradation of elastin.

Exhibits antioxidant effects – Protects against oxidative stress.

Boosts hydration – Supports skin moisturization.

Recommended Usage: 0.5–1.0%

2. Product Specifications

Item Specification
Appearance White to off-white solid powder
Odor Slight characteristic odor
Acid Value 110.0–140.0 mg KOH/g
Loss on Drying ≤ 1.0%
Residue on Ignition ≤ 0.5%
Inorganic Acids ≤ 0.1%

Packaging & Storage

Packing: 0.5 kg/bag
Storage: Sealed at room temperature
Shelf Life: 2 years

Comparable Products & Applications

  • SEPILIFT™ DPHP (SEPPIC)

  • Isa Knox MX-II PLATINUM Recovery Skin Toner

  • Bioderma Sensibio AR Anti-Redness Cream

  • LA MER The Moisturizing Soft Lotion

Efficacy Data

In an 8-week clinical study of 24 female volunteers:

  • VISIA® Complexion Analysis demonstrated significant improvement in wrinkle count and depth with 0.5%  DPHP cream vs. placebo control.

  • MPA®580 Cutometer testing confirmed markedly enhanced skin hydration.

Using effect

Using effect-1

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