English
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2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is an inhibitor of histone lysine-specific demethylases that targets on JMJD2A (KDM4A), KDM4C, KDM4E (IC50, 1.4 μM), KDM5B (IC50, 3 μM), KDM6A and other 2-oxogynases [1][2].
Histone lysine-specific demethylases JMJD2A (KDM4A) and KDM4C are both members of the Jumonji domain 2 (JMJD2) family and function as trimethylation-specific demethylases, converting specific trimethylated histone residues to the dimethylated form. KDM5B is an H3K4me3⁄ me2-specific lysine demethylase [1][2]
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Product Name: 2,4-Pyridinedicarboxylic acid
CAS:499-80-9
MF:C7H5NO4
MW:167.12
EC:207-892-2
Usage:
2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is an inhibitor of histone lysine-specific demethylases that targets on JMJD2A (KDM4A), KDM4C, KDM4E (IC50, 1.4 μM), KDM5B (IC50, 3 μM), KDM6A and other 2-oxogynases [1][2].
Histone lysine-specific demethylases JMJD2A (KDM4A) and KDM4C are both members of the Jumonji domain 2 (JMJD2) family and function as trimethylation-specific demethylases, converting specific trimethylated histone residues to the dimethylated form. KDM5B is an H3K4me3⁄ me2-specific lysine demethylase [1][2]
Specification:
Testing Items | Specifications |
Appearance | White to off white powder |
Identification by IR | Standard spectrum should conforms to sample spectrum |
Loss on Drying(%, w/w) | ≤3.0 |
Solubility | Soluble in 2.0N Sodium Hydroxide solution |
Purity by HPLC(%,Area) | ≥98.0 |
Package:
20kg or 25kg per drum
Product Name: 2,4-Pyridinedicarboxylic acid
CAS:499-80-9
MF:C7H5NO4
MW:167.12
EC:207-892-2
Usage:
2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is an inhibitor of histone lysine-specific demethylases that targets on JMJD2A (KDM4A), KDM4C, KDM4E (IC50, 1.4 μM), KDM5B (IC50, 3 μM), KDM6A and other 2-oxogynases [1][2].
Histone lysine-specific demethylases JMJD2A (KDM4A) and KDM4C are both members of the Jumonji domain 2 (JMJD2) family and function as trimethylation-specific demethylases, converting specific trimethylated histone residues to the dimethylated form. KDM5B is an H3K4me3⁄ me2-specific lysine demethylase [1][2]
Specification:
Testing Items | Specifications |
Appearance | White to off white powder |
Identification by IR | Standard spectrum should conforms to sample spectrum |
Loss on Drying(%, w/w) | ≤3.0 |
Solubility | Soluble in 2.0N Sodium Hydroxide solution |
Purity by HPLC(%,Area) | ≥98.0 |
Package:
20kg or 25kg per drum